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Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating

机译:体温过高的治疗计划指导下头颈部浅部肿瘤加热的涂药器选择

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摘要

textabstractPurpose: In this study, we investigated the differences in hyperthermia treatment (HT) quality between treatments applied with different hyperthermia systems for sub-superficial tumours in the head and neck (H&N) region. Materials and methods: In 24 patients, with a clinical target volume (CTV) extending up to 6 cm from the surface, we retrospectively analysed the predicted HT quality achievable by two planar applicator arrays or one phased-array hyperthermia system. Hereto, we calculated and compared the specific absorption rate (SAR) and temperature distribution coverage of the CTV and gross tumour volume (GTV) for the Lucite cone applicator (LCA: planar), current sheet applicator (CSA: planar) and the HYPERcollar (phased-array). Results: The HYPERcollar provides better SAR coverage than planar applicators if the target region is fully enclosed by its applicator frame. For targets extending outside the HYPERcollar frame, sufficient SAR coverage (25% target coverage, i.e. TC25 ≥ 75%) can still be achieved using the LCA when the target is fully under the LCA aperture and not deeper than 50 mm from the patient surface. Conclusion: Simulations predict that the HYPERcollar (hence also its successor the HYPERcollar3D) is to be preferred over planar applicators such as LCA and current sheet applicator in sub-superficial tumours in the H&N region when used within specifications.
机译:textabstract目的:在这项研究中,我们调查了针对头颈部(H&N)区域的浅表肿瘤,采用不同热疗系统进行的治疗之间的高温治疗(HT)质量之间的差异。材料和方法:在24例患者中,临床目标体积(CTV)从表面延伸至6 cm,我们回顾性分析了通过两个平面施加器阵列或一个相控阵热疗系统可达到的预计HT质量。至此,我们计算并比较了Lucite锥形涂抹器(LCA:平面),当前床单涂抹器(CSA:平面)和HYPERcollar的CTV的比吸收率(SAR)和温度分布范围以及总肿瘤体积(GTV)(相控阵)。结果:如果目标区域被其涂抹器框架完全封闭,则HYPERcollar的SAR覆盖范围比平面涂抹器好。对于延伸到HYPERcollar镜框之外的目标,当目标完全位于LCA孔下方且距患者表面不超过50mm时,使用LCA仍可实现足够的SAR覆盖率(目标覆盖率为25%,即TC25≥75%)。结论:仿真预测,在规格范围内使用时,在H&N区域的浅表肿瘤中,HYPERcollar(因此也是其后继产品HYPERcollar3D)优于平面涂药器(例如LCA和当前的薄板涂药器)。

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